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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 25808Generated: October 26, 2026

2-Phenylethanethiol → 6-(4-Methoxyphenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

https://huagongshe.com/reaction/25808

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-PhenylethanethiolHCID 78126—
Reactant(4-Methoxyphenyl)boronic acidHCID 201262—
ReactantTrifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl esterHCID 20760320—
Product6-(4-Methoxyphenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinolineHCID 10409609—

Reaction Steps

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 4-methoxyphenylboronic acid. Bromination and coupling reaction with 2-phenylethanethiol gave 15 mg of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06858627B2
Source datasetuspto-grants-2005_02
ORD IDord-76ddf474d34a452a8fdcc9fc59869736
Source noteuspto-grants-2005_02