Hydrochloric Acid → HCID 178516700, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (3RS)-1-cyanomethyl-1,3-dihydro-5phenyl-3-phthalimido-2H-1,4-benzodiazepin-2 -one (100.0 g) and sodium azide (46.4 g) in 1-methyl-2-pyrrolidone (1.74 l) was added triethylamine hydrochloride (49.1 g) under stirring. The mixture was heated on an oil-bath at 145° C. and stirred for 4 hours. The reaction mixture was poured into 5% hydrochloric acid (4.8 l) under cooling and stirring. The resultant precipitate was collected by filtration, washed with water several times and dried in vacuo at 50° C. for 5 hours to afford (3RS)-1,3-dihydro-5-phenyl-3-phthalimido-1-[(1H-tetrazol-5-yl)methyl]-2H-1,4 -benzodiazepin-2-one (100.39 g).

Provenance & Evidence