HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-1-(4-methylphenyl)ethan-1-one → 2-Chloro-1-(4-methylphenyl)ethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-1-(4-methylphenyl)ethan-1-one | HCID 237805 | — |
| Reactant | 2-Chloro-1-(m-tolyl)ethanol | HCID 13736674 | — |
| Reactant | 2-Chloro-1-(2-methylphenyl)ethan-1-one | HCID 19070807 | — |
| Reactant | 2-Chloro-1-(3-methylphenyl)ethanone | HCID 22248821 | — |
| Reactant | 2-Chloro-1-(2-methylphenyl)ethanol | HCID 22621576 | — |
| Product | 2-Chloro-1-(4-methylphenyl)ethan-1-ol | HCID 12300418 | — |
Reaction Steps
Cultivation, reaction and purification were carried out in the same way as described in Example 9 except that 2-chloro-1-(2'-methylphenyl) ethanone, 2-chloro-1-(3'-methylphenyl) ethanone, 2-chloro-1-(4'-methylphenyl) ethanone were used as substrate, and (-)-2-chloro-1-(2'-methylphenyl) ethanol, (-)-2-chloro-1-(3'-methylphenyl) ethanol, (-)-2-chloro-1-(4'-methylphenyl) ethanol were obtained. The yield, specific rotation and optical purity determined by high-performance liquid chromatography were shown in Table 6.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05266485 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-ec896a0080ac4289a57f1677af505f47 |
| Source note | uspto-grants-1993_11 |