2-Chloro-1-(2,5-dimethoxyphenyl)ethanone → 2-Chloro-1-(3,4-dimethoxyphenyl)ethan-1-ol

HRID 258228Notes

Reaction equation

HRID 258228 reaction equation
ClCC(C1C=C(OC)C=CC=1OC)=O.[Cl:15][CH2:16][C:17]([C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([O:27][CH3:28])[CH:20]=1)=[O:18].ClCC(C1C=C(OC)C=CC=1OC)O>>[Cl:15][CH2:16][CH:17]([C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([O:27][CH3:28])[CH:20]=1)[OH:18]

Participants

4

Reactant 3

HCID 2736162-Chloro-1-(2,5-dimethoxyphenyl)ethanoneHCID 122925932-Chloro-1-(3,4-dimethoxyphenyl)ethanoneHCID 232071012-Chloro-1-(2,5-dimethoxyphenyl)ethan-1-ol

Product 1

HCID 142885082-Chloro-1-(3,4-dimethoxyphenyl)ethan-1-ol

Procedure

Cultivation, reaction and purification were carried out in the same way as described in Example 9 except that 2-chloro-1-(2',5'-dimethoxyphenyl) ethanone, 2-chloro-1-(3',4'-dimethoxyphenyl) ethanone were used as substrate and (-)-2-chloro-1-(2',5'-dimethoxyphenyl) ethanol, (-)-2-chloro-1-(3',4'-dimethoxyphenyl) ethanol were obtained. The yield, specific rotation and optical purity determined by high-performance liquid chromatography were shown in Table 10.

Workup

  1. customCultivation, reaction and purification

Sources & evidence

ORD record
ord-9a8007b831c549f9b125be1efb6d57c8
Source dataset
uspto-grants-1993_11
Patent number
US05266485

Reaction notes

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