Sodium Hydroxide → HCID 19737156, compound

Participants

Reaction Steps

A solution of 30.5 g of 2-cyano-5-[3,6-dihydro-3,4-dimethyl-2,6-dioxo-1(2H)-pyrimidinyl]-4-fluorobenzoic acid isopropyl ester (see Example 1) in 150 ml of methanol is maintained at 1°-3° C. for 15 minutes with 4.0 g of sodium hydroxide in 50 ml of water and then stirred for 23 hours. The solution is substantially concentrated by evaporation under reduced pressure and the residue is adjusted to a pH value of 2 with 2N hydrochloric acid. The resulting precipitate is filtered off with suction and subsequently washed with n-hexane to yield 2-cyano-5-[3,6-dihydro-3,4-dimethyl-2,6-dioxo-1(2H)-pyrimidinyl]-4-fluorobenzoic acid, m.p. 232° C. (with decomposition).

Provenance & Evidence