Thionyl Chloride → HCID 54489017, compound

Participants

Reaction Steps

A mixture of 3.0 g of finely pulverised 2-cyano-5-[3,6-dihydro-3,4-dimethyl-2,6-dioxo-1(2H)-pyrimidinyl]-4-fluorobenzoic acid, 30 ml of freshly distilled thionyl chloride and 3 drops of dimethylformamide is heated at reflux temperature for 1 hour with stirring, after which a clear solution has formed. The mixture is then concentrated to dryness by evaporation to yield 2-cyano-5-[3,6-dihydro-3,4-dimethyl-2,6-dioxo-1(2H)-pyrimidinyl]-4-fluorobenzoic acid chloride, m.p. 160° C., which is used, unpurified, as the starting material in the next reaction step.

Provenance & Evidence