Water → HCID 135749813, compound

Participants

Reaction Steps

To a solution of methyl 1-(2,6-dichloro-4-trifluoromethylphenyl)-5-nitroindazol-6-yl carbonate (8 g) in ethanol (100 g), 30% sulfuric acid (20 ml) was added, and the resultant mixture was refluxed for 6 hours. After completion of the reaction, the reaction mixture was poured into water and extracted with diethyl ether. The extract was dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with hexane-ethyl acetate (4:1) to give 1-(2,6-dichloro-4-trifluoromethylphenyl)-6-hydroxy-5-nitroindazole (4.1 g).

Provenance & Evidence