Nitric Acid → HCID 19737198, compound

Participants

Reaction Steps

To a solution of methyl 1-(3-chloro-5-trifluoromethylpyridin-2-yl)indazol-6-yl carbonate [Compound No. 39] (10 g) in conc. sulfuric acid (100 g), fuming nitric acid (3.5 g) was added dropwise while cooling with ice, and the resultant mixture was stirred at room temperature for 3 hours. After completion of the reaction, the reaction mixture was poured into ice water, and the precipitated crystals were collected by filtration, washed and dried. The crystals were purified by silica gel column chromatography with hexane-ethyl acetate (4:1) to give methyl 1-(3-chloro-5-trifluoromethylpyridin-2-yl)-5-nitroindazol-6-yl carbonate (8.2 g).

Provenance & Evidence