HCID 19737189, compound → HCID 178506244, compound

Participants

Reaction Steps

To a solution of 1-(3-chloro-5-trifluoromethylpyridin-2-yl)-5,6-diaminoindazole [Compound No. 81] (5.0 g) in acetic acid (20 g), a solution of sodium nitrite (0.9 g) in water (3 ml) was added dropwise at room temperature. After completion of the reaction, the reaction mixture was poured into water, and the precipitated crystals were collected by filtration, washed and dried. The crystals were purified by silica gel column chromatography with hexane-ethyl acetate (4:1) to give 5-(3-chloro-5-trifluoromethylpyridin-2-yl)[1,2,3]triazolo[4,5-f]indazole (5.0 g).

Provenance & Evidence