Water → HCID 19737204, compound

Participants

Reaction Steps

To a solution of 5-(3-chloro-5-trifluoromethylpyridin-2-yl)[1,2,3]triazolo[4,5-f]indazole [Compound No. 48] (1.0 g) in N,N-dimethylformamide (10 g), methyl 2-bromopropionate (0.5 g) and potassium carbonate (1 g) were added, and the resultant mixture was stirred at 40° C. for 3 hours. After completion of the reaction, the reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed, dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with hexane-ethyl acetate (4:1) to give 5-(3-chloro-5-trifluoromethylpyridin-2-yl)-3-(1-methoxycarbonylethyl)[1,2,3]triazolo[4,5-f]indazole (0.3 g) and 5-(3-chloro-5-trifluoromethylpyridin-2-yl)-1-(1-methoxycarbonylethyl)[1,2,3]triazolo[4,5-f]indazole (0.1 g).

Provenance & Evidence