Ethoxyacetic acid → N-(1-[9,10-Dihydro-9,10-methanoanthracen-9-ylmethyl]-4-piperidyl)-2-ethoxyacetamide

Participants

Reaction Steps

Using a procedure similar to that described in Example 1 except starting with 4-amino-1-[9,10-dihydro-9,10-methanoanthracen-9-ylmethyl]piperidine and 2-ethoxyacetic acid, the title compound was obtained as a white solid (76%), mp 158.0°-9.0° C.; MS(CI): 391 (M+H); NMR (300 MHz,DMSO-d6): 1.12(t, 3H, J=7.0 Hz), 1.41-1.69(m, 4H), 2.27(m, 2H), 2.45(s, 2H), 2.95(m, 2H), 2.95(m, 2H), 3.45(q, 2H, J=7.0 Hz), 3.63(m, 1H), 3.78(s, 2H), 4.31(s, 1H), 6.92(m, 4H), 7.17-7.23(m, 4H), 7.47(d, 2H, J=8.0 Hz).

Provenance & Evidence