2-Chloro-5-fluoropyrimidin-4-amine → 4-Amino-2-[1-(9,10-dihydro-9,10-methanoanthracen-9-ylmethyl)-4-piperidylamino]-5-fluoropyrimidine

Participants

Reaction Steps

Using a procedure similar to that described in Example 86 except starting with 4-amino-1-(9,10-dihydro-9,10-methanoanthracen-9-ylmethyl)piperidine (prepared as described in Example 8b) and 4-amino-2-chloro-5-fluoropyrimidine, the hydrochloride salt of the title compound was obtained as a white solid (8%), mp 250°-254° C.; MS(CI): 416 (M+H); NMR (300 MHz, DMSO-d6): 10.25(br s, 1H), 8.60(br m, 1H), 8.10(m, 1H), 7.39-7.32(m, 4H), 7.03-6.95(m, 4H), 4.46(s, 1H), 4.36(s, 2H), 4.18-3.80(br m, 1H), 3.60-3.38(m, 4H), 2.75(s, 2H), 2.14-1.96(m, 4H).

Provenance & Evidence