反应详情

A solution of 1-tert-butoxycarbonylamino-3-azabicyclo-[4.1.0]heptane (200 mg, 0.94 mmol) and the ethyl ester of 7-chloro-6-fluoro-1-(2,4-difluorophenyl) 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (327 mg, 0.85 mmol) in acetonitrile (12 ml) was heated at reflux for 3 hours. Solvent was removed in vacuo, and the residue was chromatographed on silica gel (eluant: 50% ethyl acetate/-hexane) to afford the title produce as an off-white solid (423 mg, 0.758 mmol, 88% yield).

1. temperatureat reflux for 3 hours
2. customSolvent was removed in vacuo
3. customthe residue was chromatographed on silica gel (eluant: 50% ethyl acetate/-hexane)
4. customto afford the title