HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 131717647, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 7-(1-tert-Butoxycarbonylamino-3-azabicyclo[4.1.0]-hept-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, ethyl ester | HCID 86746342 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 131717647 | HCID 131717647 | 62% |
Reaction Steps
A solution of the compound of step A (300 mg, 0.54 mmol) in ethyl acetate (6 ml) and 3N hydrochloric acid (6 ml) was heated to reflux overnight. Solvents were removed in vacuo, and the residue was recrystallized from methanol-acetonitrile to give the title product as a white solid, mp>192° C. (decomp.) (155.5 mg, 0.338 mmol, 62% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05266569 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-cb6092fad5004d93b892030891ab969a |
| Source note | uspto-grants-1993_11 |