HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → ((3-((7-Chloro-2-quinolinyl)methoxy)phenyl)methyl)triphenylphosphonium bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 2-((3-(Bromomethyl)phenoxy)methyl)-7-chloroquinoline | HCID 19737237 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | ((3-((7-Chloro-2-quinolinyl)methoxy)phenyl)methyl)triphenylphosphonium bromide | HCID 88417068 | 98.5% |
Reaction Steps
The bromide of Step 3 (26.45 g, 72.9 mmol) and triphenylphosphine (28.7 g, 109 mmol) were heated to reflux in CH3CN (250 mL) for 7 hours. At r.t., ether was added and an oil separated, which crystallized on trituration. The solid was filtered and was swished with ether for 20 hours to yield 44.87 g (98%) of the title phosphonium salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05266568 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-714fb2a721da4fe497cb00166ba07611 |
| Source note | uspto-grants-1993_11 |