Methyl iodide → Methyl 2-(3-(3-(diphenyl(2-methyl-2-propyl)siloxy)phenyl)-3-hydroxypropyl)benzoat

Participants

Reaction Steps

To the product of Example 2, Step 1 (95 g, 0.187 mol) in acetone (1 L) was added K2CO3 (55 g, 0.374 mol) and MeI (128 mL, 1.31 mol). After refluxing for 1.5 h, the reaction mixture was cooled to r.t. EtOAc (1 L) was then added to the reaction mixture and the K2CO3 was removed by filtration. The filtrate was evaporated to dryness to provide 93 g (98%) of the title ester.

Provenance & Evidence