3-Methyl-3-sulfanylbutanoic acid → 3-((1(R)-(3-((7-chloro-2-quinolinyl)methoxy)phenyl)-3-(2-(2-hydroxy-2-propyl)phenyl)-propyl)thio)-3-methylbutanoic acid

HRID 258488Notes

Reaction equation

HRID 258488 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH2:12][O:13][C:14]3[CH:15]=[C:16]([C@H:20](O)[CH2:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[C:29]([O:32]C4CCCCO4)([CH3:31])[CH3:30])[CH:17]=[CH:18][CH:19]=3)=[N:9]2)=[CH:4][CH:3]=1.[SH:40][C:41]([CH3:47])([CH3:46])[CH2:42][C:43]([OH:45])=[O:44]>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH2:12][O:13][C:14]3[CH:15]=[C:16]([C@H:20]([S:40][C:41]([CH3:47])([CH3:46])[CH2:42][C:43]([OH:45])=[O:44])[CH2:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[C:29]([OH:32])([CH3:30])[CH3:31])[CH:17]=[CH:18][CH:19]=3)=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 98127863-Methyl-3-sulfanylbutanoic acidHCID 228488501-(R)-(3-((7-chloro-2-quinolinyl)methoxy)phenyl)-3-(2-(2-(2-tetrahydropyranyloxy)-2-propyl)phenyl)propanol

Product 1

HCID 228488573-((1(R)-(3-((7-chloro-2-quinolinyl)methoxy)phenyl)-3-(2-(2-hydroxy-2-propyl)phenyl)-propyl)thio)-3-methylbutanoic acid

Procedure

The title compound was prepared using the enantiomer of the alcohol of Example 6, Step 8, and 3-mercapto-3-methylbutanoic acid, following Method J.

Sources & evidence

ORD record
ord-35770e86f6054ed789271283c3130cdb
Source dataset
uspto-grants-1993_11
Patent number
US05266568

Reaction notes

Loading…