HCID 20373042, compound → HCID 178518872, compound

HRID 258540Notes

Reaction equation

HRID 258540 reaction equation
C([O:8][C:9]1[C:15](=[O:16])[N:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:13]2[CH:23]=[C:24]([Cl:27])[CH:25]=[CH:26][C:12]=2[N:11]2[C:28](=[O:31])[N:29]=[N:30][C:10]=12)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[OH:8][C:9]1[C:15](=[O:16])[N:14]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:13]2[CH:23]=[C:24]([Cl:27])[CH:25]=[CH:26][C:12]=2[N:11]2[C:28](=[O:31])[N:29]=[N:30][C:10]=12

Participants

5

Reactant 2

HCID 20373042HCID 20373042, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 178518872HCID 178518872, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

44.6 g of 4-(benzyloxy)-8-chloro-6-phenyl-1H-s-triazolo[4,3-a][1,5]benzodiazepine-1,5-dione in 400 ml of ethanol containing 2.0 g of 10% palladium-on-charcoal is hydrogenated at an initial hydrogen pressure of 40 p.s.i. After 0.1 mole of hydrogen has been absorbed, the reaction is stopped, filtered and the solvent evaporated. The residue is triturated with ether and the title compound filtered off and dried.

Workup

  1. filtrationfiltered
  2. customthe solvent evaporated
  3. customThe residue is triturated with ether
  4. filtrationthe title compound filtered off
  5. customdried

Sources & evidence

ORD record
ord-1be0b437a39841219ca66747fbed94fd
Source dataset
uspto-grants-1977_07
Patent number
US04033947

Reaction notes

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