HCID 20373050, compound → HCID 20373036, compound

HRID 258542Notes

Reaction equation

HRID 258542 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14](=[O:17])[N:15]=[N:16][C:12]3=[CH:11][C:10](=[O:18])[N:9]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:8]=2[CH:25]=1)([O-])=O.[H][H]>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14](=[O:17])[N:15]=[N:16][C:12]3=[CH:11][C:10](=[O:18])[N:9]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:8]=2[CH:25]=1

Participants

5

Reactant 2

HCID 20373050HCID 20373050, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 20373036HCID 20373036, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

33.5 g of 8-nitro-6-phenyl-1H-s-triazolo[4,3-a] [1,5]-benzodiazepine-1,5-dione in 100 ml of ethanol containing 2.0 g of 10% palladium-on-charcoal is hydrogenated at room temperature at an initial hydrogen pressure of 50 p.s.i. The reaction is stopped when 0.3 moles of hydrogen has been absorbed; the suspension is filtered and the filtrate evaporated to give the title compound.

Workup

  1. customhas been absorbed
  2. filtrationthe suspension is filtered
  3. customthe filtrate evaporated

Sources & evidence

ORD record
ord-45142249548b4038b607dbe17f42aaa8
Source dataset
uspto-grants-1977_07
Patent number
US04033947

Reaction notes

Loading…