Ethanol → HCID 20373047, compound

HRID 258544Notes

Reaction equation

HRID 258544 reaction equation
[CH2:1]([N:8]([CH2:10][CH2:11][N:12]1[C:33](=[O:34])[N:15]2[C:16]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][C:17]=3[N:18]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19](=[O:21])[CH:20]=[C:14]2[NH:13]1)C)C1C=CC=CC=1.[CH2:35](O)C>[Pd]>[CH3:1][NH:8][CH:10]([CH3:35])[CH2:11][N:12]1[C:33](=[O:34])[N:15]2[C:16]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][C:17]=3[N:18]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[C:19](=[O:21])[CH:20]=[C:14]2[NH:13]1

Participants

4

Reactant 2

HCID 702EthanolHCID 20373043HCID 20373043, compound

Product 1

HCID 20373047HCID 20373047, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

4 g of 2-[2-(N-benzyl-N-methylamino)ethyl]-8-chloro-6-phenyl-1H-s-triazolo[4,3-a] [1,5]benzodiazepine-1,5-dione in 100 ml of ethanol containing 0.4 g of 5% palladium on charcoal is hydrogenated at 50 p.s.i. hydrogen pressure until 1 molar equivalent of hydrogen is absorbed. The suspension is filtered and the filtrate is evaporated. The residue is triturated with a small amount of cold ether and the title compound is filtered off and dried.

Workup

  1. customhydrogen pressure until 1 molar equivalent of hydrogen is absorbed
  2. filtrationThe suspension is filtered
  3. customthe filtrate is evaporated
  4. customThe residue is triturated with a small amount of cold ether
  5. filtrationthe title compound is filtered off
  6. customdried

Sources & evidence

ORD record
ord-cf5ff39465574576b13f3984426db749
Source dataset
uspto-grants-1977_07
Patent number
US04033947

Reaction notes

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