HuagongsheHuagongshe Chemistry Print Report · For research reference only
Anthranilic Acid → 11-Oxo-11H-pyrido(2,1-b)quinazoline-8-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Anthranilic Acid | HCID 227 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-Chloronicotinic acid | HCID 79222 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 11-Oxo-11H-pyrido(2,1-b)quinazoline-8-carboxylic acid | HCID 198439 | 44.5% |
Reaction Steps
A reaction mixture containing 4.35g (31.8 mmol) of anthranilic acid, 5.00g (31.8 mmol) of 6-chloronicotinic acid, 3ml of conc. HCl and 80ml of ethanol was heated at reflux for 21 hours. The mixture was cooled and filtered to give 3.40g (38.9%) of the expected product, mp. 323° -325° dec. The analytical sample was obtained by recrystallization from methanol-ether, mp. 323° -325° dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04033961 |
| Source dataset | uspto-grants-1977_07 |
| ORD ID | ord-8d3df2ae831d47c9b887a350c9374a89 |
| Source note | uspto-grants-1977_07 |