HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-Chloro-3-(hydroxymethyl)oxazolo(4,5-b)pyridin-2(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one | HCID 13614459 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-Chloro-3-(hydroxymethyl)oxazolo(4,5-b)pyridin-2(3H)-one | HCID 21426072 | 85% |
Reaction Steps
8 parts of 38% formaldehyde solution and 25 parts of 2N hydrochloric acid are added to a solution of 8.5 parts of 6-chlorooxazolo-[4,5-b]-pyridin-2-(3H)-one in 60 parts of water, and the whole is stirred for 4 hours at 50° to 60° C. After cooling with ice, filtration is performed and the residue is washed with ice water. There are obtained 8.5 parts of 3-hydroxymethyl-6-chloro-oxazolo[ 4,5-b]pyridin-2-(3H)-one (85% of theory), m.p. 137°-139° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04033975 |
| Source dataset | uspto-grants-1977_07 |
| ORD ID | ord-0b89a3058bee48e3b6d1cac7a8a983e1 |
| Source note | uspto-grants-1977_07 |