Methanol → p-Chloro-o-toluidine hydrochloride

関与物質

反応手順

79 g (1.1 moles) of chlorine is introduced into a solution of 135 g (1 mole) of 2 -formylaminotoluene in 500 ml of chloroform at 20° to 25° C. in the course of 2 to 3 hours. After the addition of 28 g (0.88 mole) of methanol, the mixture obtained is stirred for 2 hours at 25° to 30° C., and the formed 2 -amino-5 -chlorotoluene hydrochloride is subsequently filtered off. There is obtained 130 g (73% of theory relative to 2 -formylaminotoluene) of 2 -amino-5 -chlorotoluene hydrochloride. The content of 2 -amino-5 -chlorotoluene hydrochloride in the product is 98 to 99%.

情報源と証拠