Sodium Hydroxide → HCID 23684863, compound

HRID 25866Notes

Reaction equation

HRID 25866 reaction equation
[OH-].[Na+:2].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:15](=[O:16])[C:14]([C:17]([OH:19])=[O:18])=[C:13]([CH3:20])[N:12]=[CH:11]2)=[CH:6][CH:5]=1>CO>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[C:15](=[O:16])[C:14]([C:17]([O-:19])=[O:18])=[C:13]([CH3:20])[N:12]=[CH:11]2)=[CH:8][CH:9]=1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 213255011-(4-Chlorophenyl)-1,6-dihydro-4-methyl-6-oxopyrimidine-5-carboxylic acid

Product 1

HCID 23684863HCID 23684863, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 5 ml of 1.0 N aqueous sodium hydroxide solution (5.0 mmoles) diluted with 50 ml of methanol is added one equivalent of 1-(4-chlorophenyl)-1,6-dihydro-4-methyl-6-oxopyrimidine-5-carboxylic acid prepared as in Example 2. After stirring for a short time the resulting slurry (pH 7-8) is evaporated in vacuo. The solid residue is slurried in ether and isolated by vacuum filtration. Drying gives a quantitative yield of sodium 1-(4-chlorophenyl)-1,6-dihydro-4-methyl-6-oxopyrimidine-5-carboxylate, m.p. >250° C.

Workup

  1. additionis added
  2. customis evaporated in vacuo
  3. customisolated by vacuum filtration
  4. customDrying

Sources & evidence

ORD record
ord-e527c729fc964c4c914e8b9b7b79ee52
Source dataset
uspto-grants-1979_04
Patent number
US04147528

Reaction notes

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