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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 25868Generated: October 25, 2026

Ethyl orthoformate → Ethyl 1-(4-Chlorophenyl)-1,6-dihydro-2,4-dimethyl-6-oxopyrimidine-5-carboxylate

https://huagongshe.com/reaction/25868

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl orthoformateHCID 31214—
ReactantTriethyl orthoacetateHCID 66221—
ReactantEthyl 3-amino-2-(4-chlorophenylcarbamoyl)crotonateHCID 70610046—
ProductEthyl 1-(4-Chlorophenyl)-1,6-dihydro-2,4-dimethyl-6-oxopyrimidine-5-carboxylateHCID 2132548942%

Reaction Steps

This compound is prepared in 42% yield from ethyl 3-amino-2-(4-chlorophenylcarbamoyl)crotonate in a manner analogous to Example 1 substituting triethyl orthoacetate for triethyl orthoformate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04147528
Source datasetuspto-grants-1979_04
ORD IDord-507868586bd341fa949a7da51d5fcec3
Source noteuspto-grants-1979_04