HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 5-Oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 5-Oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine | HCID 22756839 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid | HCID 22756824 | — |
Reaction Steps
0.6 g. of this ester and 10 cm3 of a 10% solution of Na2CO3 are heated under reflux for 20 minutes. After cooling, the solution is acidified by means of acetic acid. The precipitate (0.5 g.) is filtered off and recrystallised from water. 0.2 g. of 5-oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid is obtained, melting point 225° C. (decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04034094 |
| Source dataset | uspto-grants-1977_07 |
| ORD ID | ord-b47ace057db945e5bce2bb1787c5afc8 |
| Source note | uspto-grants-1977_07 |