1-Ethylpiperazine → 2-(4'-Ethylpiperazino)-5-oxo-8-ethyl-6-carbethoxy-5,8-dihydro-pyrido(2,3-d)pyrimidine

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Reaction Steps

3.8 g of 2-chloro-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3 -d)pyrimidine and 2.9 g of 1-ethyl-piperazine, dissolved in 50 cm3 of chloroform, are heated under reflux for 2 hours. After cooling, the organic solution is washed with water and dried over MgSO4 ; the solvent is evaporated and the residue is recrystallised from a mixture of isopropyl ether (15 cm3) and benzene (25 cm3) and gives 4.4 g (yield: 93%) of 2-(4'-ethyl-piperazino)5-oxo-8-ethyl-6-carbethoxy-5,8 -dihydro-pyrido(2,3 -d)pyrimidine; melting point 161° C.

Provenance & Evidence