2-[(4-Hydroxynaphthalen-1-yl)oxy]propanoic acid → HCID 23456142, compound

Participants

Reaction Steps

To a solution of 38.0 g potassium dihydrogen phosphate in 7.5 l of distilled water (pH 4.0) was added 89.4 g (0.33 mol) potassium nitrosodisulfonate (Fremy's reagent). To this solution was added immediately a solution of 34.8 g (0.15 mol) of 2-(4-hydroxy-1-naphthoxy)propionic acid in 125 ml ethanol. The mixture was stirred for 2.5 hours under nitrogen at room temperature. The yellow-brown solid was collected, washed with a litter water and dried (under nitrogen). The yield was 30.0 g (81 percent). The crude product melted at 182° to 184° C.

Provenance & Evidence