Benzenesulfonyl chloride → 4-Benzenesulphonamido-1-(4-p-chlorophenyl-4-oxobutyl)piperidine

HRID 258718Notes

Reaction equation

[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][C:11]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)=[O:12])[CH2:4][CH2:3]1.[C:20]1([S:26](Cl)(=[O:28])=[O:27])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[C:20]1([S:26]([NH:1][CH:2]2[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)=[O:12])[CH2:4][CH2:3]2)(=[O:28])=[O:27])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

Reactant 2

HCID 7369Benzenesulfonyl chloride

HCID 23368200HCID 23368200, compound

Product 1

HCID 214265264-Benzenesulphonamido-1-(4-p-chlorophenyl-4-oxobutyl)piperidine

Procedure

Using an analogous procedure to Example 2 4-amino-1-(4-p-chlorophenyl-4-oxobutyl)piperidine may be reacted with benzenesulphonyl chloride to give the title compound.

Sources & evidence

ORD record: ord-af60c9842272449fb7bc651f58992c80
Source dataset: uspto-grants-1977_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04034098

Reaction notes

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