Cyclohexanesulfonyl chloride → 4-Cyclohexanesulphonamido-1-(4-phenyl-4-oxobutyl)piperidine

HRID 258719Notes

Reaction equation

[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:12])[CH2:4][CH2:3]1.[CH:19]1([S:25](Cl)(=[O:27])=[O:26])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[CH:19]1([S:25]([NH:1][CH:2]2[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][C:11]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)=[O:12])[CH2:4][CH2:3]2)(=[O:27])=[O:26])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

Reactant 2

HCID 237554Cyclohexanesulfonyl chloride

HCID 126085374-Amino-1-(4-phenyl-4-oxobutyl)piperidine

Product 1

HCID 542805504-Cyclohexanesulphonamido-1-(4-phenyl-4-oxobutyl)piperidine

Procedure

Using an analogous procedure to Example 2 4-amino-1-(4-phenyl-4-oxobutyl)piperidine may be reacted with cyclohexanesulphonyl chloride to give the title compound.

Sources & evidence

ORD record: ord-1492f0f02dd847649dc34ad434c8f57b
Source dataset: uspto-grants-1977_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04034098

Reaction notes

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