HRID258751

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2768918

O-propylhydroxylamine

C3H9NO

HCID3014370

Hydroxylamine, O-butyl-

C4H11NO

结构：Cc1nc[nH]c1CSCCN=C(N)N(O)CCSCc1[nH]cnc1C.Cl.Cl.Cl

HCID178433318

未命名化合物

HCID178485010

未命名化合物

PRODUCTS

生成物

HCID178454581

未命名化合物

HCID178460301

未命名化合物

PROCEDURE

实验过程

Reaction of the isothiourea dihydrochloride of Example 1 (i) with n-propoxyamine and n-butyoxyamine according to the procedure of Example 1 (ii) gave respectively N-methyl-N'-n-propoxy-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride and N-methyl-N'-n-butoxy-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-692b49d5bc2641e8962ebf0e7e328df1
来源数据集: uspto-grants-1977_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04034101
来源说明: uspto-grants-1977_07

反应 SMILES

[ClH:1].Cl.[OH:3][NH:4][C:5]([NH:17][CH3:18])=[N:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16].[CH2:19](ON)[CH2:20][CH3:21].[CH2:24]([O:28][NH2:29])[CH2:25][CH2:26][CH3:27].Cl.Cl.Cl.O[N:34]([CH2:48]CSCC1NC=NC=1C)[C:35](N)=[N:36][CH2:37][CH2:38][S:39][CH2:40][C:41]1[NH:45][CH:44]=[N:43][C:42]=1[CH3:46]>>[ClH:1].[ClH:1].[CH3:18][NH:17][C:5]([NH:4][O:3][CH2:19][CH2:20][CH3:21])=[N:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16].[ClH:1].[ClH:1].[CH3:48][NH:34][C:35]([NH:29][O:28][CH2:24][CH2:25][CH2:26][CH3:27])=[N:36][CH2:37][CH2:38][S:39][CH2:40][C:41]1[NH:45][CH:44]=[N:43][C:42]=1[CH3:46]