Ethyl 2-[4-(Methylsulfonamido)phenyl]acetate → 1-(2-Cyanophenoxy)-3-beta-(4-methanesulphonamidophenylacetamido)ethylamino-2-propanol
Reaction equation
[NH2:1][CH2:2][CH2:3][NH:4][CH2:5][CH:6]([OH:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]#[N:16].[CH3:18][S:19]([NH:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30](OCC)=[O:31])=[CH:25][CH:24]=1)(=[O:21])=[O:20]>>[C:15]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:7][CH:6]([OH:17])[CH2:5][NH:4][CH2:3][CH2:2][NH:1][C:30](=[O:31])[CH2:29][C:26]1[CH:25]=[CH:24][C:23]([NH:22][S:19]([CH3:18])(=[O:20])=[O:21])=[CH:28][CH:27]=1)#[N:16]Participants
3
Procedure
In a similar manner using 1.2 g. of 3-(β-aminoethylamino)-1-(2-cyanophenoxy)-2-propanol and 1.29 g. of ethyl 4-methanesulphonamidophenylacetate as starting materials there is obtained 1-(2-cyanophenoxy)-3-β-(4-methanesulphonamidophenylacetamido)ethylamino-2-propanol, isolated as its oxalate, m.p. 180°-182° C. after crystallisation from isopropanol.
Sources & evidence
- ORD record
- ord-5cbf5780c1854c409b3da4ca1180e79f
- Source dataset
- uspto-grants-1977_07
- Patent number
- US04034106
Reaction notes
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