Water → 2-Amino-4-ethylthio-1-(3-methoxycarbonyl-2-thioureido)benzene

HRID 258761Notes

Reaction equation

HRID 258761 reaction equation
[CH2:1]([S:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([NH:13][C:14]([O:16][CH3:17])=[O:15])=[S:12])=[C:6]([N+:18]([O-])=O)[CH:5]=1)[CH3:2].O>CO>[NH2:18][C:6]1[CH:5]=[C:4]([S:3][CH2:1][CH3:2])[CH:9]=[CH:8][C:7]=1[NH:10][C:11]([NH:13][C:14]([O:16][CH3:17])=[O:15])=[S:12]

Participants

4

Reactant 2

HCID 962WaterHCID 203720534-Ethylthio-1-(3-methoxycarbonyl-2-thioureido)-2-nitrobenzene

Product 1

HCID 203720472-Amino-4-ethylthio-1-(3-methoxycarbonyl-2-thioureido)benzeneYield 59.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A mixture of 4-ethylthio-1-(3-methoxycarbonyl-2-thioureido)-2-nitrobenzene (14.0 g.), ferrous chloride tetrahydrate (3.04 g.), methanol (235 ml.) and water (50 ml.) was heated to reflux and treated with reduced iron powder (15.5 g.) portionwise during 5 minutes. The mixture was heated at reflux with stirring for one hour. Methanol (250 ml.) was added and the mixture was again heated to reflux. The hot mixture was filtered and the filtrate was allowed to cool to room temperature. The solid which crystallised on cooling was filtered off to give 2-amino-4-ethylthio-1-(3-methoxycarbonyl-2-thioureido)benzene (7.5 g.), m.p. 168° C.

Workup

  1. temperaturewas heated
  2. temperatureto reflux
  3. temperatureThe mixture was heated
  4. temperatureat reflux
  5. temperaturethe mixture was again heated to reflux
  6. filtrationThe hot mixture was filtered
  7. customThe solid which crystallised
  8. temperatureon cooling
  9. filtrationwas filtered off

Sources & evidence

ORD record
ord-7c8ad2b44c48474cb5eb69917516bdcf
Source dataset
uspto-grants-1977_07
Patent number
US04034107

Reaction notes

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