反应详情

A solution of 4-amino-3-nitrophenol (17.5 g.) in ethanol (300 ml.) was treated with solid potassium hydroxide (6.38 g.). The mixture was treated with a solution of 2 -bromoethyl ethyl thioether (21.2 g.) in ethanol (100 ml.), and stirred at room temperature for 4 hours. The reaction mixture was then concentrated in vacuo and the residue was dissolved in chloroform (200 ml.). The chloroform solution was washed with aqueous sodium bicarbonate solution (10% w/v; 200 ml.), dried over magnesium sulphate and evaporated to give 4-[2-(ethylthio)ethoxy]-2-nitroaniline (23.4 g.) in the form of a dark red oil, which was used in the next stage without further purification being necessary.

1. concentrationThe reaction mixture was then concentrated in vacuo
2. dissolutionthe residue was dissolved in chloroform (200 ml.)
3. washThe chloroform solution was washed with aqueous sodium bicarbonate solution (10% w/v; 200 ml.)
4. dry with materialdried over magnesium sulphate
5. customevaporated