Guaiacol → HCID 50177, compound

Participants

Reaction Conditions

Reaction Steps

To 10 ml. of dioxane are added 1.5 ml. of 37 % formalin and 2.42 g. of phenethylamine, followed by the addition of 3.2 g. of ortho-methoxyphenol dissolved in 3 ml. of dioxane. The mixture is heated at 100° C for 4 hours and distilled under reduced pressure to remove the solvent. The residue is purified by column chromatography on silica gel with a mixture of acetone and benzene (1:4) to obtain 2-methoxy-6-phenethylaminomethylphenol as an oil. Yield: 0.7 g.

Provenance & Evidence