Hydrochloric Acid → HCID 21424809, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 20 parts of 2-[(2-amino-5-chlorophenyl)-amino]ethanol and 18 parts of urea is stirred and heated for 4 hours in an oil-bath at about 190° C. The reaction mixture is cooled and dissolved in alkaline water. The solution is acidified with a concentrated hydrochloric acid solution. The precipitated product is filtered off, washed with water and dried, yielding 13 parts (57.1%) of 6-chloro-1,3-dihydro-1-(2-hydroxyethyl)-2H-benzimidazol-2-one; mp. 160° C.

Provenance & Evidence