反应详情

A mixture of 5 parts of 1-acetyl-4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]piperidine and 100 parts of sodium hydroxide solution 10% is stirred and refluxed overnight. The reaction mixture is cooled and the product is extracted with trichloromethane. The extract is dried, filtered and evaporated. The solid residue is stirred in 2,2'-oxybispropane. The product is filtered off and dried in vacuo at 40° C, yielding 3.5 parts (82%) of 4-[2(4-fluorophenyl)-1,3-dioxolan-2-yl]-piperidine.

1. temperaturerefluxed overnight
2. temperatureThe reaction mixture is cooled
3. extractionthe product is extracted with trichloromethane
4. customThe extract is dried
5. filtrationfiltered
6. customevaporated
7. stirringThe solid residue is stirred in 2,2'-oxybispropane
8. filtrationThe product is filtered off
9. customdried in vacuo at 40° C