Thionyl Chloride → HCID 70637434, compound

HRID 258927Notes

Reaction equation

HRID 258927 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[C:9]([CH3:17])=[CH:10][CH:11]=[CH:12][C:13]=1[CH:14](O)[CH3:15])=[O:7].S(Cl)([Cl:20])=O>C1C=CC=CC=1>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[C:9]([CH3:17])=[CH:10][CH:11]=[CH:12][C:13]=1[CH:14]([Cl:20])[CH3:15])=[O:7]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 70637620HCID 70637620, compound

Product 1

HCID 70637434HCID 70637434, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 14.7 parts of 3-(1-hydroxyethyl)-o-tolyl 2-thienyl ketone and 126 parts of benzene is stirred while cooling on an ice-bath. Then 9.5 parts of thionyl chloride are added and the whole is stirred further over week-end at room temperature. The reaction mixture is evaporated in vacuo, yielding 3-(1-chloroethyl)-o-tolyl 2-thienyl ketone as a residue.

Workup

  1. temperaturewhile cooling on an ice-bath
  2. stirringthe whole is stirred further over week-end at room temperature
  3. customThe reaction mixture is evaporated in vacuo

Sources & evidence

ORD record
ord-964fcc2b9b02407abd5a8ee5170ff9b2
Source dataset
uspto-grants-1977_07
Patent number
US04035376

Reaction notes

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