反应详情

To a solution of 4.7 g. (0.026 mole) of 7-methyl-8-quinolinecarboxylic acid, 3.9 g. (0.037 mole) of 5-aminotetrazole hydrate in 30 ml. of pyridine and 50 ml. of chloroform is added dropwise with stirring 5.6 ml. of thionyl chloride. The mixture is stirred at 70° C. for about one hour. The reaction mixture is evaporated to provide a residue which is diluted with water. The precipitate is separated by filtration and recrystallized from acetic acid. The product is again recrystallized from ethanol to provide 7-methyl-8-(1H-tetrazole-5-ylcarbamoyl)quinoline, m.p. 285°-287° C.

1. stirringThe mixture is stirred at 70° C. for about one hour
2. customThe reaction mixture is evaporated
3. customto provide a residue which
4. customThe precipitate is separated by filtration
5. customrecrystallized from acetic acid
6. customThe product is again recrystallized from ethanol