HCID 21425193, compound → HCID 21425190, compound

Participants

Reaction Steps

1.3-bis(p-methoxyphenyl)cyclobutanol (13.2 g., 0.046 mole), 3.0 g. of 10% Pd/c, 1 ml. of 70% HClO4, and 100 ml. of 95% EtOH is shaken under 50 psi of H2 until hydrogen absorption is complete. The catalyst is removed by filtration and the filtrate is evaporated. A solution of the residue in ether is washed (5% Na HCO3, water) and dried (MgSO4). Evaporation of the ether yields a residue (11.4 g.) which is recrystallized (EtOH), affording 6.8 g. (55%) of the desired intermediate.

Provenance & Evidence