Potassium Hydroxide → HCID 21425203, compound

HRID 258968Notes

Reaction equation

HRID 258968 reaction equation
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14])=[CH:8][CH:7]=1)(=O)C.[OH-].[K+]>C(O)C.O>[C:12]([C:9]1[CH:8]=[CH:7][C:6]([CH2:5][OH:4])=[CH:11][CH:10]=1)(=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 21409404HCID 21409404, compound

Product 1

HCID 21425203HCID 21425203, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of 15 grams (0.064 mole) of α-acetoxy-p-pivaloyl-toluene and 15 grams (0.278 mole) of potassium hydroxide in 150 milliliter of ethanol and 50 milliliters of water is refluxed for 4 hours. The solvent is removed in vacuo, and the residue is treated with ether and water. The ether is separated and the water is again extracted with ether. The ether layers are combined, decolorized with charcoal, dried over magnesium sulfate, filtered and evaporated. The resulting yellow oil is distilled in vacuo to give p-pivaloyl benzyl alcohol (b.p. 100° to 105° C./0.1 milliliters).

Workup

  1. temperatureis refluxed for 4 hours
  2. customThe solvent is removed in vacuo
  3. additionthe residue is treated with ether and water
  4. customThe ether is separated
  5. extractionthe water is again extracted with ether
  6. dry with materialdried over magnesium sulfate
  7. filtrationfiltered
  8. customevaporated
  9. distillationThe resulting yellow oil is distilled in vacuo

Sources & evidence

ORD record
ord-8a86d2fbf0034877ac11b4e1e0f2d326
Source dataset
uspto-grants-1977_07
Patent number
US04035427

Reaction notes

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