HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-[4-(1-Adamantyl)-phenoxy]-butyric acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-[4-(1-Adamantyl)-phenoxy]-butyric acid chloride | HCID 54017807 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 4-[4-(1-Adamantyl)-phenoxy]-butyric acid amide | HCID 54040458 | — |
Reaction Steps
A strong stream of dry ammonia is passed (for 15 minutes) into a solution of 16.5 g of 4-[4-(1-adamantyl)-phenoxy]-butyric acid chloride in 150 ml of absolute benzene under anhydrous conditions, whilst stirring. The product formed is now filtered off and washed with ehter. Recrystallisation from a large amoumt of acetone yields pure 4-[4-(1-adamantyl)-phenoxy]-butyric acid amide of melting point 176°-177° C (needles).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04035413 |
| Source dataset | uspto-grants-1977_07 |
| ORD ID | ord-ee2ee75828f540679cbacda3fd511014 |
| Source note | uspto-grants-1977_07 |