Methanol → HCID 54384546, compound

Participants

Reaction Steps

Nα-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-tyrosyl-O-benzyl-L-seryl-D-alanine resin, 7.1 g., prepared in Example 1 is mixed with methanol, 600 ml., and triethylamine, 60 ml., at room temperature for 2 days. After filtration and evaporation, the crude product, 2.7 g., is chromatographed on silica gel with chloroform-methanol-water (60:30:5) to yield 1.9 g., m.p. 178°-182° C.

Provenance & Evidence