Methanol → HCID 68118693, compound

Participants

Reaction Steps

In 20 ml. of methanol is dissolved 300 mg. of trans-6-benzyloxy-2-cyclobutylamino-1-hydroxy-5-hydroxymethyl-1,2,3,4-tetrahydronaphthalene and catalytic reduction is carried out in the presence of 5% palladium-on-carbon as the catalyst. When no more hydrogen is absorbed, the catalyst is filtered off and 60 mg. of acetic acid is added to the filtrate. The mixture is concentrated under reduced pressure and the residue is recrystallized from methanolethyl acetate. The procedure yields trans-2-cyclobutylamino-1,6-dihydroxy-5-hydroxymethyl-1,2,3,4-tetrahydronaphthalene acetate as colorless platelets melting at 143°-145° C (decomp.)

Provenance & Evidence