Acetic Acid → HCID 12340652, compound

Participants

Reaction Steps

A mixture of 18 ml of 40% aqueous dimethylamine solution and 19.8 ml of acetic acid is treated with 9 ml of 37% formalin at 10° - 15° C. The resulting solution is added at once to 10 g of 4,4-dimethyl-4H-pyrrolo[2,1-c][1,4]benzoxazine (10. g, described in Example 78) in 30 ml of ethanol. The reaction mixture is stirred at ambient temperature for 18 hr. Ethanol is removed under reduced pressure, and the remaining oily suspension is extracted with chloroform. The combined extracts are dried (Na2SO4), filtered, and evaporated to yield the title compound, nmr (CDCl3) δ 1.56 (s, 6H), 2.67 (d, J = 4.5Hz, 6H), 4.70 (d, J = 4.5Hz, 2H), 6.08 and 6.85 (d, 2H), 6.95 - 7.70 (m, 4H), 12.4 (broad, 1H).

Provenance & Evidence