Hydrochloric Acid → HCID 21425307, compound

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Reaction Steps

Alternatively, the procedure of this Example is followed to prepare compounds of formula 3 in which R2 is CH2NR4R5 in which R4 and R5 are as defined herein and A is COOR6 or CONR4R5 in which R4, R5 or R6 are as defined herein. For example, by using dimethylamine (40% aqueous solution) as the base and N-isopropyl-4-methyl-4H-pyrrolo[2,1-c][1,4]benzoxazine-4-carboxamide, described in Example 15, 1-[(dimethylamino)methyl]-N-isopropyl-4-methyl-4H-pyrrolo-2,1-c][1,4]benzoxazine-4-carboxamide, nmr (CDCl3) δ 1.02 and 1.16 (2 xd, J = 7Hz, 6H), 1.75 (s, 3H), 2.70 (d, J = 4Hz, 6H), is obtained. [The corresponding hydrochloric acid addition salt of the latter compound has m.p. 125° - 127° C). Reduction of the latter compound according to the procedure of Example 42 yields 1-[(dimethylamino)-methyl]-4-[(isopropylamino)methyl]-4-methyl-4H-pyrrolo[2,1-c][1,4]-benzoxazine.

Provenance & Evidence