p-Toluenesulfonic acid → HCID 21422793, compound

Participants

Reaction Steps

52 g of ethyl orthoformate and 1 g of p-toluene sulfonic acid were added to a solution of 59 g of the product of Step A in 180 ml of methanol and the mixture was stirred at room temperature for 7 hours. The mixture was then allowed to stand for 18 hours and 1 ml of quinoline was added thereto. The solvent was evaporated and the residue was chromatographed over silica gel. Elution with an 8-2 methylene chloride-acetone mixture gave 20 g of m-(n-butylcarbamoyloxy)-3,3-diethoxy-butyranilide melting at 130°C.

Provenance & Evidence