反应详情

To a solution of 0.9 grams of 3,4-dimethoxy-3-cyclobutene-1,2-dione dissolved in 10 ml. of absolute ethanol is added 1.8 grams of 1-butylpiperazine in 5 ml. of absolute ethanol. The reaction mixture is stirred overnight at room temperature under a nitrogen atmosphere. Then, the solvent is removed with a nitrogen stream, 5 ml. of anhydrous ethyl ether is added, and the resultant solid is filtered, washed with ethyl ether, and dried in air. The resulting product, 3,4-bis(4-butyl-1-piperazinyl)-3-cyclobutene-1,2-dione is obtained as white crystals melting at approximately 137.5°-139° C.

1. customThen, the solvent is removed with a nitrogen stream, 5 ml
2. additionof anhydrous ethyl ether is added
3. filtrationthe resultant solid is filtered
4. washwashed with ethyl ether
5. customdried in air