Methane → HCID 21423021, compound

Participants

Reaction Steps

To a stirred, refluxing solution of 2.2 grams of 3-(4-ethyl-1-piperazinyl)-4-methoxy-3-cyclobutene-1,2-dione dissolved in 30 ml. of absolute ethanol under an atmosphere of dry nitrogen, is added a solution of 1.0 gram of 1-methylpiperazine in 30 ml. of absolute ethanol. The resulting mixture is refluxed for 4 hours and then stripped of solvent under reduced pressure until the volume is approximately 15 ml. The concentrate is treated with decolorizing charcoal and filtered through a bed of diatomaceous earth. Crystallization is induced in the filtrate and the resulting crystalline precipitate is filtered, washed with absolute ethanol, and dried in a steam cabinet. The resulting product, 3-(4-ethyl-1-piperazinyl)-4-(4-methyl-1-piperazinyl)-3-cyclobutene-1,2-dione, is obtained as white crystals melting at about 166.5°-169° C. This product is represented by the following structural formula. ##STR9##

Provenance & Evidence