3-Cyclobutene-1,2-dione, 3,4-dimethoxy- → HCID 21423019, compound

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Reaction Steps

A solution of 1.5 grams of 2,6-dimethyl-1-propylpiperazine in 10 ml. of methanol is mixed with a solution of 3,4-dimethoxy-3-cyclobutene-1,2-dione in 25 ml. of methanol and refluxed for 5 hours. The solvent is then evaporated by heating on a steam bath and the resulting red semi-crystalline residue is triturated with anhydrous ethyl ether and filtered and the filter cake is washed with 5 ml. of anhydrous ethyl ether to remove the colored by-products and leave 3,4-bis(3,5-dimethyl-4-propyl-1-piperazinyl)-3-cyclobutene-1,2-dione as a grey-white crystalline solid melting at about 145°-147° C.

Provenance & Evidence